Nodular fasciitis is rare in the breast parenchyma. ; Pullitzer, D.; Horenstein, MG.; Prieto, VG. Fibrous scar resembling fibromatosis. Myofibroblastic sarcoma. Hanft, VN. "Cellular angiofibroma: clinicopathologic and immunohistochemical analysis of 51 cases.". ; Nascimento, AG. Low-magnification view shows a well-circumscribed border. The nuclei are separate from each other, without significant overlapping. Spindle cell sarcoma is a type of cancer which occurs on the connective tissues of the body. Fibromatosis. Plasma cell myeloma with spindle cell morphology is a rare histologic variant that necessitates the exclusion of other spindle cell neoplasms that can occur in bone, such as systemic mastocytosis, metastatic carcinoma, melanoma, or sarcoma, with spindled morphology or … A dense, fibrocollagenous process is seen partially encircling a breast lobule, Fibromatosis on core biopsy. Spindle cell lesions of the breast cover a wide spectrum of diseases ranging from reactive tumor-like lesions to high-grade malignant tumors. Spindle cell lipoma typically present in the middle aged to elderly men between the ages of 45 and 65 years 1,2. "Leydig cell tumors of the testis with unusual features: adipose differentiation, calcification with ossification, and spindle-shaped tumor cells.". Ulbright, TM. ; Mentzel, T.; Newman, PL. The organised fibrosis reflects tissue injury that was more remote, which can be temporally compared with when the biopsy was performed. A few foreign-body-type, multinucleated giant cells are seen amid the fibrosis. Although both luminal epithelial and myoepithelial cells may assume spindle shapes, spindle cell lesions of the breast usually refer to conditions that are composed of mesenchymal or mesenchymal-like cells that harbour elongated and stretched cytoplasm. Division of Pathology, Singapore General Hospital, Singapore, Singapore, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA. Fibromatosis can mimic breast malignancy, presenting as an ill-defined mass with spiculations, typically adjacent to or arising from the pectoralis muscle. Memory device SCADS or CAD SS = S-100, CD34, AE1/AE3, Desmin, SMA. Mesenchymal-like malignant epithelial cells are encountered in fibromatosis-like and spindle cell metaplastic carcinomas. The spindle cell process has low cellularity, with a few chronic inflammatory cell infiltrates, Fibromatosis on core biopsy. There have been anecdotal reports of sarcomas of myofibroblastic origin (Figs. It occurs most frequently in adult males in their 40s to 60s. Some of the spindle cells appear relatively plump and are aligned in a vaguely linear fashion, which can mimic an invasive lobular carcinoma of classic type, especially when nuclear reactivity for oestrogen receptor is seen (which can be encountered in myofibroblastoma). metaplastic carcinoma. Adapted from Miller with modifications:[1]. It starts with just a small lump and inflammation and then the symptoms slowly progress as the cancer grows from one stage to another. •Usually uniform spindle cells with hyperchromatic nuclei and often some degree of pleomorphism; mitoses (low grade may not show them) and often necrosis •Any mitotic figures in an otherwise neurofibroma-like lesion with increased cellularity and nuclear atypia warrants the diagnosis of MPNST in … High magnification shows slender, elongated, and slightly wavy nuclei with tapered ends. Cut section shows a whitish appearance with slightly rubbery consistency and a few linear indentations, Myofibroblastoma. With the history of a prior core biopsy, a differential that needs to be excluded is fibrous scarring, but this excision was performed within a week after the core biopsy, and histologically the reparative process would comprise relatively fresh granulation rather than a fibrous-like lesion. Intra‐abdominal spindle cell lesions are uncommon and often present a diagnostic challenge. Ganesan, R.; McCluggage, WG. Spindle cells should make think: 1. Spindle cell lipomas have a wide variety of appearances. Interphase nuclei show rearrangement of the ALK break-apart probe using fluorescence in situ hybridisation. A variety of different lesions may comprise mesenchymal spindle cells, including nodular fasciitis, fibrous scarring, pseudoangiomatous stromal hyperplasia, myofibroblastoma, fibromatosis, stromal overgrowth in phyllodes tumour, and sarcoma. It is usually hypoechoic on sonography because of its fibrous content [. ; Srigley, JR.; Hatzianastassiou, DK. Excision biopsy shows the stellate outlines of the lesion at low magnification. Spindle cell hemangioendothelioma. Monomorphic - small variation of tumour cell size. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. Diagnosing this is particularly problematic but important when encountered in a needle core biopsy, as treatments of different entities are different. (Jan 2000). Smooth muscle tumors are considered in Chapter 6. The recognition of the benign spindle cell tumor-like lesions (nodular fasciitis; reactive spindle cell nodule after biopsy, inflammatory pseudotumor/inflamma …
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