(check all that apply). 2009;18(11):2957-2964. Keep in mind that natural products are not always necessarily safe and dosages can be important. Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent. View abstract. Chang, Y. C., Riby, J., Chang, G. H., Peng, B. C., Firestone, G., and Bjeldanes, L. F. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, a major in vivo product of dietary indole-3-carbinol. B. and Ichikawa, H. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. 2009;15(8):1164-1173. View abstract. View abstract. Carcinogenesis 2005;26(4):771-778. View abstract. View abstract. View abstract. A controlled safety study of diindolylmethane in the immature rat model. Gong, Y., Sohn, H., Xue, L., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells. No cash value. Another best DIM supplement that improves levels of favorable estrogen is Nature’s Way. It warns of the complications of poor estrogen management such as, water retention, male breasts, fat gain and irritability. Supplementing with DIM in low amounts may help prevent cancer, aid weight loss, and provide estrogen balancing. In Vivo 2006;20(2):221-228. 2014 Sep 23;111(7):1269-74. 2007;137(1):31-36. Cancer Epidemiol.Biomarkers Prev. Wang, T. T., Milner, M. J., Milner, J. J.Nutr. 11-1-2009;108(4):916-925. A., and Kim, Y. S. Estrogen receptor alpha as a target for indole-3-carbinol. Zhonghua Yi.Xue.Za Zhi. are there any negative health effects associated with taking red ginseng and dim (diindolylmethane) which is a natural estrogen blocker? Carcinogenesis 2001;22(11):1809-1817. Aggarwal, B. Cancer Lett 2000;151:169-79. Parkin, D. R. and Malejka-Giganti, D. Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3'-diindolylmethane and its parent compound indole-3-carbinol. 2006;169(5):1833-1842. CONDITIONS OF USE AND IMPORTANT INFORMATION: Nutr Cancer 2004;50(2):161-167. Am.J.Pathol. View abstract. Bradlow HL, Sepkovic DW, Telang NT, Osborne MP. Cancer Detect.Prev. Distributed by Direct Digital, LLC, Charlotte, NC 28202, https://www.gnc.com/muscle-builders/452396.html. View abstract. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. View abstract. 5-18-2005;53(10):3895-3901. J.Cell Biochem. Indole-3-carbinol (IC3) is a substance found in cruciferous vegetables like … Arazo Nutrition Tribulus Testosterone Booster with Estrogen Blocker. 2006;69(2):430-439. Rajoria S, Suriano R, Parmar PS, Wilson YL, Megwalu U, Moscatello A, Bradlow HL, Sepkovic DW, Geliebter J, Schantz SP, Tiwari RK. J.Nutr.Biochem. View abstract. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Biochem.Pharmacol. 3-1-2010;79(5):715-721. Mol.Pharmacol. Details of these offers will be set forth within the specific promotions. Ge, X., Fares, F. A., and Yannai, S. Induction of apoptosis in MCF-7 cells by indole-3-carbinol is independent of p53 and bax. Carcinogenesis 1998 Sep;19:1631-9. Estrohalt lowers estrogen levels from it's multiple aromatase inhibitors in DIM and Indole-3-Carbinol which reduce the conversion of … View abstract. View abstract. Kotsopoulos J, Zhang S, Akbari M, Salmena L, Llacuachaqui M, Zeligs M, Sun P, Narod SA. Have you ever purchased DIINDOLYLMETHANE? Biochem Biophys Res Commun 1996;228:153-8. View abstract. E-Block by Pride Nutrition. What factors influenced or will influence your purchase? By: Nature’s Way. 3'3-diindolylmethane induces apoptosis in human cancer cells. 5-1-2006;66(9):4880-4887. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. Estrodex by SAN is a simple formula yet a strong anti-estrogen capsule … Smith, S., Sepkovic, D., Bradlow, H. L., and Auborn, K. J. Toxicol.Sci. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. Your browser's Javascript functionality is turned off. View abstract. DIM comes from the breakdown of the phytochemical Indole 3-Carbinol and assists people who have estrogen dominance or an inordinate quantity of estrogen. Before taking diindolylmethane talk to your healthcare provider if you take any medications that are changed by the liver.Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others. 1999;19(4B):3199-3203. Some medications are changed and broken down by the liver.Diindolylmethane might increase how quickly the liver breaks down some medications. J.Nutr. Cancer Res. View abstract. View abstract. Free shipping offer does not include P.O. Studies recommend 50-300 mg per day of DIM, though this is gleaned from cancer research, not studies for overall health and vitality (10, 11). Zhao, Y. Y., Zhou, L., Pan, Y. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. J Allergy Clin Immunol Pract. One of the key super ingredients found in Nugenix Estro-Regulator is Diindolylmethane (DIM), which is an aromatase inhibitor that can help support estrogen balance - a critical factor for anyone wanting hardcore gains. 4-1-2007;67(7):3310-3319. Indole-3-Carbinol ("IC3"), is a powerful estrogen blocking chemical found in high … 2001;61(1):40-48. Am.J.Transl.Res. Estrogen blocking products can help you maintain balanced hormone levels, by lowering your estrogen and leaving room for your testosterone level to go up. Jellinck, P. H., Makin, H. L., Sepkovic, D. W., and Bradlow, H. L. Influence of indole carbinols and growth hormone on the metabolism of 4-androstenedione by rat liver microsomes. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Rahman KM, Ali S, Aboukameel A, Sarkar SH, Wang Z, Philip PA, Sakr WA, Raz A. Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells. Toxicol.Sci. Carcinogenesis 2010;31(9):1634-1641. The product quantity you requested has exceeded our Maximum Purchasing Policy of (12) items. Diindolylmethane (DIM) is a compound created when you digest cruciferous vegetables, such as broccoli or Brussels sprouts (1, 2).Research suggests that DIM affects estrogen levels in … DIM-plus contains diindolylmethane, a phytonutrient found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale. © 2005 - 2019 WebMD LLC. Marketed as an elite estrogen blocker for men, Androsurge definitely lives up to its name. Biochem.Biophys.Res.Commun. Thyroid. View abstract. Hsu, J. C., Zhang, J., Dev, A., Wing, A., Bjeldanes, L. F., and Firestone, G. L. Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells. Kim, E. J., Shin, M., Park, H., Hong, J. E., Shin, H. K., Kim, J., Kwon, D. Y., and Park, J. H. Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. Carcinogenesis 2005;26(11):1896-1904. View abstract. GNC may offer other free shipping offers periodically. Xue, L., Firestone, G. L., and Bjeldanes, L. F. DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways. 6-1-2009;107(3):516-527. Firestone, G. L. and Bjeldanes, L. F. Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions. Before looking at some products you can use for lowering your estrogen levels, let’s see when exactly do you need an estrogen blocker. Nutr.Cancer 2001;41(1-2):57-63. Solaray Indole-3-Carbinol. Kim, Y. H., Kwon, H. S., Kim, D. H., Shin, E. K., Kang, Y. H., Park, J. H., Shin, H. K., and Kim, J. K. 3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. Beyond this, the top-ranked estrogen blockers all do a great job balancing out active ingredients, so it’s hard to go wrong foll… View abstract. 2001;131(12):3294-3302. Note: This product cannot be sold in Chang, X., Tou, J. C., Hong, C., Kim, H. A., Riby, J. E., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice. Kim, E. J., Park, S. Y., Shin, H. K., Kwon, D. Y., Surh, Y. J., and Park, J. H. Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. Overall, this activity can diminish the impact estrogen has in the body!*. 2010;78(2):297-309. Riby, J. E., Xue, L., Chatterji, U., Bjeldanes, E. L., Firestone, G. L., and Bjeldanes, L. F. Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells. View abstract. Bui PV, Moualla M, Upson DJ. 1978;38(5):1410-1413. J.Cell Biochem. Tribulus Terrestris 1500MG … Cell Cycle 2005;4(9):1201-1215. When you're estrogen dominant, finding relief improves the quality of your life. Available at: https://ntp-server.niehs.nih.gov. Carcinogenesis 2002;23(8):1297-1305. 9-1-2009;78(5):469-476. Chen I, McDougal A, Wang F, Safe S. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. View abstract. Cancer Res. How Long Does Coronavirus Live On Surfaces? Mol.Endocrinol. Leong, H., Riby, J. E., Firestone, G. L., and Bjeldanes, L. F. Potent ligand-independent estrogen receptor activation by 3,3'-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways. Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with DIINDOLYLMETHANE. Li, Y., Li, X., and Sarkar, F. H. Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis. I have tried many supplements. 2016;2016:7527098. View abstract. This supplement is made up of a number of natural estrogen blockers, including vitamin D, Zinc, and grape seed extract. Made with a powerful, key ingredient called Diindolylmethane (DIM), this specially formulated estrogen regulator is essential for guys who want to unlock serious gains for their body and love life Combat lower T levels with one of the best estro-blockers on the market. View abstract. View abstract. View abstract. All rights reserved. Aromatase inhibitors are used in the treatment of breast cancer to reduce levels of circulating estrogen. Nachshon-Kedmi, M., Yannai, S., Haj, A., and Fares, F. A. Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells. IronMag Labs - E-Control Rx 2.0. View abstract. View abstract. Pharm.Res. 1-15-2009;15(2):543-552. 2003;74(1):10-21. View abstract. View abstract. View abstract. Kong, D., Li, Y., Wang, Z., Banerjee, S., and Sarkar, F. H. Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. View abstract. View abstract. Cancer Epidemiol.Biomarkers Prev. 1-15-2010;70(2):646-654. View abstract. 2004;28(1):72-79. Press question mark to learn the rest of the keyboard shortcuts Valid at GNC.com or when calling 1-877-GNC-4700. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. Chen I, Safe S, Bjeldanes L. Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells. J.Steroid Biochem.Mol.Biol. Estrodex. 2011 Mar;21(3):299-304. Breast Cancer Res.Treat. McGuire, K. P., Ngoubilly, N., Neavyn, M., and Lanza-Jacoby, S. 3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. You have been signed up for email subscriptions! © 1997-2020 General Nutrition Centers, Inc. Go PRO for 6X Cash Back Rewards + FREE GNC Face Mask During PRO Days, If you are using a screen reader and are having problems using this website, please call, Vitamin E (as d-alpha-tocopherol succinate), Polygonum cuspidatum Extract (Root)(50% Trans-Resveratrol), A powerful anti-aromatase modulator featuring Chrysin and DIM, Helps To: Support Estrogen Regulation*, Reduce Aromatization of Testosterone, and  Support Hormonal Balance*. View abstract. 2006;19(3):436-442. Dim – Diindolylmethane is an anti-estrogen The discovery of DIM stems from research on the anticancer potential of a diet high in cruciferous brassica vegetables such as broccoli, broccoli sprouts, radishes, pak Choy, kale, brussels sprouts and cabbages. Most people only consider the amount of testosterone they need for their muscle growth, but you also should consider the estrogen that will rise in response. Where did you or where do you plan to purchase this product? IronMag Labs E-Control helps reduce estrogen while lowering … Li, Y., Wang, Z., Kong, D., Murthy, S., Dou, Q. P., Sheng, S., Reddy, G. P., and Sarkar, F. H. Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. View abstract. Hong, C., Kim, H. A., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression. View abstract. One of DIM’s primary effects involves the hormone estrogen. 7-1-2007;67(13):6502-6511. [3,3-diindolylmethane enhances the inhibitory effect of idarubicin on the growth of human prostate cancer cells]. View abstract. Indole-3-carbinol. Smith, T. K., Lund, E. K., Clarke, R. G., Bennett, R. N., and Johnson, I. T. Effects of Brussels sprout juice on the cell cycle and adhesion of human colorectal carcinoma cells (HT29) in vitro. Oncogene 3-31-2005;24(14):2343-2353. DECREASE ESTROGEN WITH ANTI-ESTROGENS. Bhuiyan, M. M., Li, Y., Banerjee, S., Ahmed, F., Wang, Z., Ali, S., and Sarkar, F. H. Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells. View abstract. Nugenix® Estro-Regulator is a powerful, cutting-edge supplement that can be stacked with Nugenix Free Testosterone Booster in order to maximize results. View abstract. Chen, D. Z., Qi, M., Auborn, K. J., and Carter, T. H. Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells. 2001;66(2):147-157. BRCA1 mRNA levels following a 4-6-week intervention with oral 3,3'-diindolylmethane. Biochem.Pharmacol. Anticancer Res. That is why these supplements are sometimes called "DIM estrogen blockers". Ahmad, A., Kong, D., Sarkar, S. H., Wang, Z., Banerjee, S., and Sarkar, F. H. Inactivation of uPA and its receptor uPAR by 3,3'-diindolylmethane (DIM) leads to the inhibition of prostate cancer cell growth and migration. In vitro evidence demonstrates DIM's anti-estrogen activity -- Through its interaction with estrogen binding sites, it can help inhibit the reaction that converts testosterone into estrogen. 2008;138(12):2379-2385. Br J Cancer. Canada. View abstract. Chen, Y., Xu, J., Jhala, N., Pawar, P., Zhu, Z. DIM and IC3 helps to encourage estrogen metabolism. View abstract. B., Ma, L., Byon, C. H., and McDonald, J. M. Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein. Mol.Pharmacol. View abstract. Laryngoscope 2009;119(9):1803-1808. Cancer Res. 3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study. 2008;7(6):1708-1719. Kassie, F., Melkamu, T., Endalew, A., Upadhyaya, P., Luo, X., and Hecht, S. S. Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination. 2006;20(2):295-305. View abstract. The most potent estrogen blockers and aromatase inhibitors are: Download PDF | Share Estrogen is required for good health. In some cases, that may not be available or it may … Not valid on previous purchases, exchanges or special orders. Anticancer Drugs 2010;21(9):814-822. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. I'm mainly wondering because many women claim to have had … 2015 Aug;42(4):401-8. Yang G, Wang Y, Tian J, Liu JP. Balk JL. Altern Med Alert 2000; 3:105-7. Clin.Cancer Res. mTOR is absolutely critical to growth hormone or … You can, instead, reach out for an estrogen blocker. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Its three-in-one supplement blend will benefit you of a bo… E-Block is an estrogen inhibitor made by Pride Nutrition. Kandala, P. K. and Srivastava, S. K. Activation of checkpoint kinase 2 by 3,3'-diindolylmethane is required for causing G2/M cell cycle arrest in human ovarian cancer cells. Estrogen blockers are not only for bodybuilders though because such effects can be helpful for regular men and women who wish to have healthy levels of estrogen and other hormones. Mol.Cancer Ther. McDougal A, Gupta MS, Ramamoorthy K, et al. One of the key super ingredients found in Nugenix Estro-Regulator is Diindolylmethane (DIM), which is an aromatase inhibitor that can help support estrogen balance - a critical factor for anyone wanting hardcore gains. Sepkovic, D. W., Bradlow, H. L., and Bell, M. Quantitative determination of 3,3'-diindolylmethane in urine of individuals receiving indole-3-carbinol. View abstract. Estrodex by S.A.N. View abstract. 2008;17(10):2619-2624. But the problem with this paradigm is that estrogen … Wattenberg, L. W. and Loub, W. D. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles. View abstract. Please turn it on so that you can experience the full capabilities of this site. Degner, S. C., Papoutsis, A. J., Selmin, O., and Romagnolo, D. F. Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells. 11-25-2005;337(3):1019-1025. Indole-3-carbinol. Abdelrahim, M., Newman, K., Vanderlaag, K., Samudio, I., and Safe, S. 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. J.Biol.Chem. View abstract. In fact, it is a miraculous hormone. Estrogen blocker supplements have been taken commonly among bodybuilders since they help reduce bloat and also provide a slender and much more defined body. The idea of a men’s estrogen blocker is rather simple on paper, but elusive in reality. Information from this source is evidence-based and objective, and without commercial influence. View abstract. It contains DIM, … Azmi, A. S., Ahmad, A., Banerjee, S., Rangnekar, V. M., Mohammad, R. M., and Sarkar, F. H. Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM). Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. View abstract. Tadi, K., Chang, Y., Ashok, B. T., Chen, Y., Moscatello, A., Schaefer, S. D., Schantz, S. P., Policastro, A. J., Geliebter, J., and Tiwari, R. K. 3,3'-Diindolylmethane, a cruciferous vegetable derived synthetic anti-proliferative compound in thyroid disease. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Japan, The logic is that by blocking estrogen, you will create more room for testosterone, thus providing muscle fullness and better muscle catabolism. Staub, R. E., Onisko, B., and Bjeldanes, L. F. Fate of 3,3'-diindolylmethane in cultured MCF-7 human breast cancer cells. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. 2016 Jan-Feb;4(1):175-6. Chem.Res.Toxicol. I have hand picked two natural test boosters that you may wish to consider that include good and proven test boosting ingredients plus the estrogen blockers. A. View abstract. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. View abstract. Anticancer Drugs 1998;9(2):141-148. Jin, Y., Zou, X., and Feng, X. 3-9-1993;45(5):1129-1136. Void where prohibited, taxed or restricted by law. View abstract. Kassie, F., Anderson, L. B., Scherber, R., Yu, N., Lahti, D., Upadhyaya, P., and Hecht, S. S. Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Carcinogenesis 2006;27(4):717-728. Cancer Res. Cancer Res. View abstract. Taking diindolylmethane along with some medications that are changed by the liver can decrease the effectiveness of some medications. Inflamm.Bowel.Dis. For women, too much estrogen increases the risk for breast, ovarian, and endometrial cancers. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. As DIM interacts with the estrogen binding places in the body, the estrogen formation process is hampered and it gets converted into testosterone. Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro. DIM works as an aromatase inhibitor for maintaining a proper estrogen balance – one of the essential things for a hardcore bodybuilder. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . 6-6-2003;278(23):21136-21145. No substitutions or backorders. 5-1-2006;66(9):4952-4960. DIM Supplements Many holistic and natural health food stores offer DIM supplements. View abstract. Free shipping offer does not apply when shipping to Alaska, Hawaii or Puerto Rico. Check Price on Amazon AnaBlox Xtreme Estrogen Blocker reduces estrogen by blocking the conversion of testosterone to estrogen. View abstract. Rahman, K. W., Li, Y., Wang, Z., Sarkar, S. H., and Sarkar, F. H. Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells. 2010;116(3):464-467. Biochem Pharmacol. View abstract. Biochem.Pharmacol. Ichite, N., Chougule, M. B., Jackson, T., Fulzele, S. V., Safe, S., and Singh, M. Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer.
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